Recent Research
Stay up-to-date on the advancing field of HCT with short summaries and links to the most relevant published research.
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No Benefit of Additional Treatment After Auto-HCT for Myeloma with Lenalidomide Maintenance
December 2016Stadtmauer E, et al. ASH abstract oral presentation, December 2016 – The addition of consolidation therapy or a second autologous transplant is not superior to a single autologous transplant followed by lenalidomide maintenance in the upfront treatment of multiple myeloma, according to research presented at the Late-Breaking Abstracts session at ASH. -
High-Risk Patients with AML Undergoing Early HCT Have Improved Outcomes
December 2016Pagel JM, et al. ASH abstract oral presentation, December 2016 – In newly diagnosed adults with acute myeloid leukemia (AML), early identification of high-risk cytogenetics and HLA testing with an organized effort to identify a suitable allogeneic hematopoietic cell transplant (HCT) donor can lead to a higher transplant rate and better transplant outcomes, according to research presented at ASH. -
Adults with ALL Experience No Benefit of Consolidation Chemotherapy Prior to HCT
December 2016Bejanyan N, et al. ASH abstract oral presentation, December 2016 – Consolidation chemotherapy does not benefit adults with acute lymphoblastic leukemia (ALL) who have a readily available donor and who undergo myeloablative allogeneic hematopoietic cell transplantation (HCT) in first complete remission (CR1), according to research presented at ASH. -
Adding Sirolimus to Standard GVHD Prophylaxis Significantly Reduces Acute GVHD
December 2016Sandmaier B, et al. ASH abstract oral presentation, December 2016 – Adding sirolimus to a standard graft-versus-host disease (GVHD) prophylaxis of mycophenolate mofetil (MMF) and cyclosporine (CSP) can significantly reduce the risks of grades II-IV and III-IV acute GVHD and non-relapse mortality (NRM), according to results of a phase 3 multi-center randomized trial presented at ASH. -
Comparable HCT Survival and Incidence of Toxicity for Patients ≥60 Years
December 2016Shah GL, et al. ASH abstract oral presentation, December 2016 – Survival of patients ≥60 years undergoing ex vivo CD34+ selected reduced-intensity hematopoietic cell transplantation (HCT) was comparable to that of patients <60 years, according to research presented at ASH. -
Somatic Mutations Can Improve Transplant Prognostics in MDS
December 2016Rossi M, et al. ASH abstract oral presentation, December 2016 – In patients with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) evolving from MDS (MDS/AML), somatic mutation information can be combined with revised International Prognostic Scoring System (IPSS-R) risk categorizations to predict post-transplant relapse risk, according to research presented at ASH.